Nicholle Tom
Ryce Newton (voice)

Joel Murray
Beethoven (voice)

Dean Jones
George Newton (voice)

Kath Soucie
Alice Newton (voice)

J.D. Daniels
Ted Newton (voice)

Francesca Marie Smith
Emily Newton (voice)

Tress MacNeille
Ginger (voice)

Joe Pantoliano
Sparky (voice)

Bill Fagerbakke
Caesar (voice)

Brian George
Mr. Huggs (voice)

Scott Menville
Puff-Puff (voice)

David Doyle
Blind Shep (voice)

Hank Azaria
Killer (voice)

Maurice LaMarche
Police Officer (voice)

Justin Shenkarow
Roger (voice)

Christine Cavanaugh
Rosebud (voice)

Tony Jay
Watson (voice)

Gregg Berger
Dirt Salesman (voice)