Damon Herriman
Street Hustler Boy (voice) / First Motherless Three (voice) / First Flophouse Re...

Jason Mantzoukas
Tim Snodgrass (voice) / Second Flophouse Resident (voice)

Hana Mae Lee
Christina Smalls (voice) / Passerby 1 (voice)

Alia Shawkat
Little Grace (voice) / Woman's Voice (voice)

Tom Waits
The Narrator (voice)

Jimmi Simpson
Detective David Mills (voice)

Da'Vine Joy Randolph
Detective Gail Johnson (voice)

John C. Reilly
Donovan Smith (voice)

Bebe Neuwirth
Lady Andrea The Giant (voice)

Melissa Villaseñor
Sister Mary Margaret (voice)

Kurtwood Smith
Carpenter K. Smith (voice)

Tim Heidecker
Mayor Kevin De Maximum (voice)

Chris Conrad
Detective Nico Onasis (voice)

Julian Barratt
The Most Dangerous Man in the World (voice)

Kristen Bell
Donella Pecker (voice)

Luis Guzmán
Rodrigo Smalls (voice)

Sunita Mani
Detective Jaya Mukherjee (voice)

Caleb McLaughlin
Trevor Johnson (voice)

Tim Meadows
Jeff Thumb (voice)

Terry O'Quinn
Captain Krieger (voice)