Casey Kasem
Shaggy Rogers (voice)

Don Messick
Scooby-Doo / Scrappy-Doo (voice) / Scooby-Doo (voice)

Frank Welker
Fred Jones (voice) / Deputy Dusty / (voice)

Heather North
Daphne Blake (voice) / (voice)

Lennie Weinrib
Scrappy-Doo (voice)

Patricia Stevens
Velma Dinkley (voice)

Marla Frumkin
Velma Dinkley (voice) / Archaeologist (voice) / Wendy Airs

John Stephenson
McGee (voice) / Sylvester / Miguel Valdez / Nick Papas / Lord Silvertree / Chef

Michael Bell
Eddie Drake / Sky Skeleton / Stage-Hand / Professor Carver (voice) / Joey Casset...

Alan Oppenheimer
Mr. Percy / Mr. Husai / (voice)

Marilyn Schreffler
Lorraine / Amelia Parmer / Girlfriend / Young Girlfriend (voice)

Pat Fraley
Tiger Morris / Howard Gruger / Blue Scarab

Stan Jones
Mr. Moss / Mr. Greenfield

Jack Angel
Jerry Sloan / Brandon Davies (voice)

William Callaway
Morgan the Magician / Mr Pratt

Joan Gerber
(voice) / Lefty Callahan / Mrs. Cornell / Vampire

Ginny Tyler
Tessie

Louis Jourdan
Chuck

Marlene Aragon
Sally

Michael Rye
Crayton Aimes (voice)