Eric Wareheim
Various

Tim Heidecker
Various

John C. Reilly
Dr. Steve Brule / Dr. Steve Brule (uncredited)

Bob Odenkirk
Announcer (voice) / Cinco Announcer (voice) / Various / Romm Oah Denmirk / Paul ...

Richard Dunn
Self / Tim's Dad / Old Office Temp / Tim's Body / Pep Pep /

David Liebe Hart
Self

James Quall
Self

Bill A. Jones
Announcer (voice) / Infomercial Announcer (voice) / Channel 5 Announcer (voice) ...

Ben Hur
Self /

Ron Austar
Pierre / Pierre (uncredited) / Bride's Parents

Bob Druwing
Self / Child Clown Video Instructor (voice) / Lindsay Porch / Chanter

'Weird Al' Yankovic
Uncle Muscles / Simon

Warren Stearns
Self / Pastor / Self / Gravy Robber Trainee / Old Office Temp / Audience Member ...

Kazu Nagahama
Kaz / Birthday Party Guest / Tiny Hat Wearer / Mourner / Self / Kaz / E-Jury Guy

Zach Galifianakis
Tairy Greene / Tairy Greene as The Snuggler

Will Forte
Pall Willeaux / Will Grello / J.J. Pepper / Dr. Reid Tamaranda

Joey Brander
Seminar Student / Joey Heidecker

Rainn Wilson
Cinco Spokesman / Blind Man / Bobby Stoan (uncredited) / Video Match Client / Bo...

Palmer Scott
Self / Sit On You Guy / Sit on You Guy

Tanese Gray
Self / Game Player