Eric Wareheim
Various

Tim Heidecker
Various

John C. Reilly
Dr. Steve Brule / Dr. Steve Brule (uncredited)

Bob Odenkirk
Announcer (voice) / Cinco Announcer (voice) / Various / Thocks Announcer (voice)...

Richard Dunn
Self / Tim's Body / / Tim's Dad / Pep Pep / Old Office Temp

David Liebe Hart
Self

James Quall
Self

Bill A. Jones
Announcer (voice) / Channel 5 Announcer (voice) / Announcer / Gravy Robbers Anno...

Ben Hur
Self /

Ron Austar
Pierre / Pierre (uncredited) / Bride's Parents

Bob Druwing
Self / Chanter / Lindsay Porch / Child Clown Video Instructor (voice)

'Weird Al' Yankovic
Uncle Muscles / Simon

Warren Stearns
Self / Audience Member (uncredited) / Pastor / Self / Gravy Robber Trainee / Old...

Kazu Nagahama
Kaz / Kaz / E-Jury Guy / Mourner / Birthday Party Guest / Tiny Hat Wearer / Self

Zach Galifianakis
Tairy Greene / Tairy Greene as The Snuggler

Will Forte
Pall Willeaux / Will Grello / Dr. Reid Tamaranda / J.J. Pepper

Joey Brander
Seminar Student / Joey Heidecker

Rainn Wilson
Blind Man / Bobby Stoan / Bobby Stoan (uncredited) / Video Match Client / Cinco ...

Palmer Scott
Self / Sit On You Guy / Sit on You Guy

Tanese Gray
Self / Game Player