Rob Paulsen
Yakko Warner / Pinky / Dr. Otto Scratchansniff (voice)

Jess Harnell
Wakko Warner (voice)

Tress MacNeille
Dot Warner / Marita Hippo / Hello Nurse / Mindy's Mother (voice)

Maurice LaMarche
Brain / Squit (voice)

Nancy Cartwright
Mindy (voice)

Frank Welker
Various (voice)

Chick Vennera
Pesto (voice)

John Mariano
Bobby / Gas Station Attendant (voice)

Bernadette Peters
Rita (voice)

Sherri Stoner
Slappy Squirrel (voice)

Paxton Whitehead
King Salazar (voice)

Ben Stein
Desire Fulfillment Facilitator (voice)

Jeff Bennett
Captain of the Guard / Baloney (voice)

Paul Rugg
Mr. Director (voice)

Julie Brown
Minerva Mink (voice)

Tom Bodett
Narrator (voice)

Bobbi Page
Singer (voice)

Nathan Ruegger
Skippy Squirrel (voice)