John Ritter
Clifford the Big Red Dog (voice)

Wayne Brady
Shackelford (voice)

Grey DeLisle-Griffin
Emily Elizabeth (voice)

Jenna Elfman
Dorothy (voice)

John Goodman
George Wolfsbottom (voice)

Jess Harnell
Dirk (voice)

Kel Mitchell
T-Bone (voice)

Judge Reinhold
Larry (voice)

Kath Soucie
Jetta / Madison (voice)

Cree Summer
Cleo (voice)

Wilmer Valderrama
Rodrigo (voice)

Earl Boen
Mr. Bleakman (voice)

Cam Clarke
Mr. Mark Howard / Marcus (voice)

Teresa Ganzel
Liza (voice)

Ernie Hudson
P.T. (voice)

Nick Jameson
Sheriff Lewis (voice)

Oren Williams
Charley (voice)