Charlie Sheen
Dex Dogtective (voice)

Hilary Duff
Sunshine Goodness (voice)

Eva Longoria
Lady X (voice)

Wayne Brady
Daredevil Dan (voice)

Christopher Lloyd
Mr. Clipboard (voice)

Chris Kattan
Polar Penguin (voice)

Larry Miller
Vlad Chocool (voice)

Ed Asner
Mr. Leonard (voice)

Jerry Stiller
General X (voice)

Martin Klebba
General X / Kaptain Krispy (voice)

Christine Baranski
Hedda Shopper (voice)

Harvey Fierstein
Fat Cat Burglar (voice)

Cloris Leachman
Brand X Lunch Lady (voice)

Haylie Duff
Sweet Cakes (voice)

Shelley Morrison
Lola Frutola (voice)

Edie McClurg
Mrs. Butterworth (voice)

Greg Ellis
Hairy Hold (voice)

James Arnold Taylor
Dr. Si Nustrix / Additonal Voices (voice)

Robert Costanzo
Maximilius Moose (voice) (as Bobby Constanza)

Jeff Bennett
Lieutenant X/Additional Voices (voice)