Lacey Chabert
Eliza Thornberry (voice)

Jodi Carlisle
Marianne Thornberry (voice)

Tim Curry
Nigel Thornberry (voice)

Flea
Donald 'Donnie' Michael Thornberry (voice)

Danielle Harris
Debbie Thornberry (voice)

Tom Kane
Darwin (voice)

Betty White
Grandma Sophie (voice)

Alan Henry Brown
Sri Mayasandra (voice)

Arthur Burghardt
Rhino / Monkey (voice)

Cara DeLizia
Baru / Monkey (voice)

Moira Quirk
Rehabilitation Worker / Monkey (voice)

Dwight Schultz
Badouk / Monkey / Poacher (voice)

Tuan Tran
Kickboxing Instructor (voice)

Alfre Woodard
Medicine Woman (voice)

Dee Bradley Baker
Parrots (voice)

Patti Deutsch
Female Rhinoceros Hornbill (voice)

Clyde Kusatsu
Sun Bear (voice)

David Paymer
Male Rhinoceros Hornbill (voice)

Maureen Quinn
Lugan (voice)

Pamela Adlon
Saiful (voice)