Aislinn Derbez
Isabela (voice)

Mike Colter
Wallace Brister (voice)

Jonny Cruz
Jesus (voice)

Angélica Vale
Garcia (voice)

Vic Chao
Chiu / Lo (voice)

Danny Trejo
Baldemar / El Balde (voice)

Raúl Castillo
Nachito (voice) / (voice) / Nachito / State Police Captain (voice)

Christian Lanz
(voice) / Von / Man on TV (voice) / Jaimito (voice)

Rose Portillo
(voice)

Eric Lopez
(voice)

Philip Anthony-Rodriguez
(voice) / Melo (voice)

Fryda Wolff
(voice)

Roger Craig Smith
Larry (voice)

Luisa Leschin
(voice)

Ryan Guzman
(voice)

Nika Futterman
Young Isabela (voice)

Carlos Luna
Domingo (voice)

Tony Amendola
Padre Serrano (voice)

Jewels Jaselle
Brigida / Brigida's Brother