Clifford the Big Red Dog

Grey DeLisle
Emily Elizabeth Howard (voice) / Miss Carrington (voice) / Mrs. Howard (voice)

Cree Summer
Cleo (voice) / Mrs. Diller (voice)

John Ritter
Clifford the Big Red Dog (voice)

Kel Mitchell
T-Bone (voice)

Gary LeRoi Gray
Charley (voice)

Cam Clarke
Machiavelli "Mac" Handover (voice)

Kath Soucie
Jetta Handover (voice)

Nick Jameson
Sheriff Lewis (voice) / Mr. Kibble (voice)

Terrence 'T.C.' Carson
Samuel (voice) / Mr. Carson (voice)

Candi Milo
Ms. Martinez (voice)

Edie McClurg
Mrs. Bleakman (voice)

Tony Plana
Victor / Pedro (voice)