Maya Rudolph
Betty Hart (voice)

Ike Barinholtz
Wayne Edwards (voice)

Jillian Bell
Violet Hart (voice)

Kristen Wiig
Jenny Hart (voice)

Fortune Feimster
Brenda (voice)

Oscar Montoya
David (voice)

Drew Tarver
Randy (voice) / Charles Lee (voice) / Ned (voice) / Eddie Toiler (voice)

Kenan Thompson
Travis (voice)

Jeremy Rowley
Jimmy Lee (voice) / Uncle Tommy (voice)

David Herman
Peter (voice)

Jon Hamm
Mayor Webb (voice)

Kumail Nanjiani
Jesus (voice)

Ken Jeong
Doug (voice)

Holly Hunter
Marjune (voice)

Jack McBrayer
Parker (voice) / Deputy Tug (voice)

Swoosie Kurtz
Mee-Maw (voice)

Sal Vulcano
Bear Vulcano (voice)

Mary Steenburgen
Crystalynn (voice)

Patton Oswalt
Vohnnie Ray Power

Kristen Schaal
Stacey (voice)