Rob Paulsen
Yakko / Pinky (voice)

Jess Harnell
Wakko (voice)

Tress MacNeille
Dot (voice)

Maurice LaMarche
The Brain / Squit (voice)

Sherri Stoner
Slappy Squirrel (voice)

Chick Vennera
Pesto (voice)

John Mariano
Bobby (voice)

Nathan Ruegger
Skippy Squirrel (voice)

Nancy Cartwright
Mindy (voice)

Frank Welker
Runt / Buttons (voice)

Bernadette Peters
Rita (voice)

Paul Rugg
Mr. Director (voice) / Freakazoid (voice) / Einstein (voice) / Sy Sykman (voice)...

Jim Cummings
Narrator (voice) / Rock Singers (voice)

Mary Gross
Katie's Mom (voice)

Jeff Bennett
Captain Mel (voice) / Charlton "Baynarts" Woodchuck (voice) / Snake (voice)

Julie Brown
Minerva Mink (voice)

Luke Ruegger
The Flame (voice) / The Brave Little Trailer (voice)

Cree Summer
Elmyra (voice)

Gail Matthius
Candie Chipmunk (voice) / Yee Haw Girl (voice)

Michael McKean
Jake (voice) / Spink (voice)