Diane Guerrero
Crazy Jane

April Bowlby
Rita Farr / Elasti-Woman

Joivan Wade
Victor Stone / Cyborg

Riley Shanahan
Cliff Steele / Robotman

Matthew Zuk
Larry Trainor / Negative Man

Matt Bomer
Larry Trainor / Negative Man (voice)

Brendan Fraser
Cliff Steele / Robotman (voice)

Skye Roberts
Kay Challis

Timothy Dalton
Dr. Niles Caulder / The Chief

Michelle Gomez
Laura De Mille / Madame Rouge

Phil Morris
Silas Stone / Doctor Cowboy

Hannah Alline
Pretty Polly / Puppet Pretty Polly (voice)

Alan Tudyk
Mr. Nobody

Bethany Anne Lind
Clara Steele

Abi Monterey
Dorothy Spinner

Jackie Goldston
The Secretary

Mark Sheppard
Willoughby Kipling

Stephanie Czajkowski
Hammerhead / Puppet Hammerhead (voice)

Shay Mack
Driller Bill

Lex Lang
Candlemaker (voice)