Gina Rodriguez
Carmen Sandiego (voice)

Finn Wolfhard
Player (voice)

Kari Wahlgren
Sheena (Tigress) (voice)

Rafael Petardi
Chase Devineaux / Boat Captain (voice)

Bernardo de Paula
Jean-Paul (Le Chèvre)

Charlet Chung
Julia Argent (voice)

Mary Elizabeth McGlynn
Coach Brunt (voice)

Michael Goldsmith
Gray (Crackle) (voice)

Andrew Pifko
Antonio (El Topo) (voice)

Sumalee Montano
Lady Dokuso (voice)