Bill Nye
Self - Host

Derek Muller
Self - Correspondent

Karlie Kloss
Self - Correspondent

Prashanth Venkataramanujam
Casting Director / Self / Cookies & Cream (voice)

Nazeem Hussain
Self - Correspondent

Zach Braff
Self

Rachel Bloom
Martian / Self - Special Guest

Cece Pleasants
Self - Voice of Wilhelmina (voice) / HPV

Sanden Totten
Ebola / Self - Voice of Refrigerator (voice)

Margaret Cho
Self / Pistachio (voice)

Cara Santa Maria
Self - Panelist / Self - Correspondent

Joanna Hausmann
Self - Correspondent

Emily Calandrelli
Self - Correspondent

Desiigner
Self

Tracy Mann
Self - Panelist

Sara Benincasa
Self - Panelist

Jennifer Widerstrom
Self - Panelist

Martin Starr
Doug the Caveman

Lauren Ash
Kale

Jeff Dye
Eggplant