Mark Hamill
Senator Stampingston / Mr. Selatcia (voice)

Victor Brandt
General Crozier / Cardinal Ravenwood (voice)

Brendon Small
Skwisgaar Skwigelf / Pickles the Drummer / Nathan Explosion

Tommy Blacha
Toki Wartooth / William Murderface (voice)

Malcolm McDowell
Vater Orlaag (voice)

Laraine Newman
News Anchor / Woman (voice) / Nathan's Grandma (voice) / TV Host / Sucubboso Exp...

George Fisher
Metal Masked Assassin (voice) / Football Player (voice) / Hippie (voice) / Angry...

James Hetfield
Sniper (voice) / Lorkey (voice) / Troll (voice) / Fan #1 (voice)

King Diamond
Ronald von Moldenberg (voice) / Employee 421 (voice) / Fast Food Restaurant Mana...

Kirk Hammett
Smoked Fingers fan (voice) / Queen of Denmark (voice) / Barkeep (voice)

Jon Schnepp
Additional Voices (voice) / Dr. Gibbits (voice)

Silenoz
Yaneemango Indian (voice) / Prison Inmate (voice) / Bobby (voice)

Angela Gossow
Lavona Sucubboso (voice) / Lavona Sucubboso / Sucubboso Explosionite (voice)

Mike Patton

Laura Silverman
Rebecca Nightrod (voice) / Valerie Vransinn / Grishnack's Assistant (voice)

Devin Townsend
Teenage Fan at Juice Joint (voice) / Additional Voices (voice)

ICS Vortex
Yaneemango Indian (voice) / Mitch (voice)

Brian Posehn

Gene Hoglan

Jeff Loomis
Mr. Murderface (voice)