Mark Hamill
Senator Stampingston / Mr. Selatcia (voice)

Victor Brandt
General Crozier / Cardinal Ravenwood (voice)

Brendon Small
Skwisgaar Skwigelf / Pickles the Drummer / Nathan Explosion

Tommy Blacha
Toki Wartooth / William Murderface (voice)

Malcolm McDowell
Vater Orlaag (voice)

Laraine Newman
News Anchor / Woman (voice) / Pickles' Mom (voice) / Nathan's Grandma (voice) / ...

George Fisher
Metal Masked Assassin (voice) / Hippie (voice) / Football Player (voice) / Angry...

James Hetfield
Troll (voice) / Lorkey (voice) / Fan #1 (voice) / Sniper (voice)

King Diamond
Ronald von Moldenberg (voice) / Employee 421 (voice) / The Blues Devil (voice) /...

Kirk Hammett
Smoked Fingers fan (voice) / Queen of Denmark (voice) / Barkeep (voice)

Jon Schnepp
Additional Voices (voice) / Dr. Gibbits (voice)

Silenoz
Yaneemango Indian (voice) / Bobby (voice) / Prison Inmate (voice)

Angela Gossow
Lavona Sucubboso (voice) / Lavona Sucubboso / Sucubboso Explosionite (voice)

Mike Patton

Laura Silverman
Rebecca Nightrod (voice) / Valerie Vransinn / Grishnack's Assistant (voice)

Devin Townsend
Additional Voices (voice) / Teenage Fan at Juice Joint (voice)

ICS Vortex
Mitch (voice) / Yaneemango Indian (voice)

Brian Posehn

Gene Hoglan

Jeff Loomis
Mr. Murderface (voice)