Casey Kasem
Shaggy Rogers (voice)

Don Messick
Scooby-Doo / Scrappy-Doo (voice) / Scooby-Doo (voice)

Frank Welker
Fred Jones (voice) / Deputy Dusty / (voice)

Heather North
Daphne Blake (voice) / (voice)

Lennie Weinrib
Scrappy-Doo (voice)

Patricia Stevens
Velma Dinkley (voice)

Marla Frumkin
Velma Dinkley (voice) / Wendy Airs / Archaeologist (voice)

John Stephenson
Chef / McGee (voice) / Sylvester / Miguel Valdez / Nick Papas / Lord Silvertree

Michael Bell
Stage-Hand / Professor Carver (voice) / Joey Cassette / Eddie Drake / Sky Skelet...

Alan Oppenheimer
Mr. Percy / Mr. Husai / (voice)

Marilyn Schreffler
Amelia Parmer / Lorraine / Girlfriend / Young Girlfriend (voice)

Pat Fraley
Tiger Morris / Howard Gruger / Blue Scarab

Jack Angel
Brandon Davies (voice) / Jerry Sloan

Stan Jones
Mr. Greenfield / Mr. Moss

William Callaway
Mr Pratt / Morgan the Magician

Joan Gerber
(voice) / Lefty Callahan / Mrs. Cornell / Vampire

Ginny Tyler
Tessie

Louis Jourdan
Chuck

Marlene Aragon
Sally

Michael Rye
Crayton Aimes (voice)