Jason Marsden
Duke (voice)

Matthew Yang King
Tunnel Rat (voice)

Kevin Michael Richardson
Roadblock (voice)

Natalia Cigliuti
Scarlett (voice)

David Kaye
Main Title Narrator/Professor Patrick O'Hara

Tatyana Yassukovich
Baroness (voice) / Anastasia Cisarovna/Baroness/Receptionist (voice)

Charlie Adler
Cobra Commander (voice) / Adam DeCobray/Cobra Commander (voice) / Buzzer/Monkeyw...

Charlie Schlatter
Dr. Mindbender (voice) / Dr. Brian Bender/Dr. Mindbender/Security Chief (voice) ...

Johnny Messner
Flint (voice)

Nika Futterman
Lady Jaye (voice) / Lady Jaye/Sheriff's Clerk (voice) / Intercom Voice (voice) /...

Khary Payton
Ripcord (voice) / Wallace Weems/Ripcord/Lead Trooper (voice)

Clancy Brown
Destro (voice) / James McCullen/Truman (voice) / James McCullen/Destro/Whistlebl...

Andrew Kishino
Storm Shadow (voice) / Storm Shadow/Sgt. Wilkinson/Stalker/ Tormod Skoog (voice)...

Kim Mai Guest
Jinx (voice)

Lee Majors
General Abernathy (voice)

Brian Bloom
Zartan (voice) / Zartan/Inventor/Dispatcher Voice (voice)

Keone Young
Hard Master/Arata (voice)

Danny Cooksey
Young Snake Eyes (voice)

André Sogliuzzo
Major Bludd (voice) / Sebastian Bludd/Major Bludd/Store Manager (voice)

Stephen Stanton
Tomax/Xamot (voice)