Jean Smart
Pickles Oblong (voice)

Will Ferrell
Bob Oblong (voice)

Pamela Adlon
Milo Oblong / Jared Klimer / The Debbies (voice)

Lea DeLaria
Helga Phugly (voice)

Jeannie Elias
Beth Oblong / Creepy Susie / Mikey Butts (voice)

Randy Sklar
Biff Oblong (voice)

Jason Sklar
Chip Oblong (voice)

Billy West
George Klimer (voice)

Becky Thyre
Jawless Peggy Weggy / Pristine Klimer / Debbie Klimer (voice)

Laraine Newman
Additional Voices (voice) / Mrs. Hubbard (voice) / Nurse Rench (voice)

Maurice LaMarche
Tommy Vinegar (voice) / Additional Voices (voice) / Renolds (voice)

Jim Cummings
Additional Voices (voice) / Laslow Institute Therapist (voice) / Sewer Workers (...

Debra Wilson
Principal Davis (voice)

Carrie Aizley
Additional Voices (voice)

Mark Hamill
Mr. Phugly (voice)

Susan Krebs
Mrs. Phugly (voice)

Dan Green
CEO Guard (voice)

Phil LaMarr
Additional Voices (voice)

Michelle Ruff
Yvette (voice)

Jim Ward
Willy (voice)