Johnny Yong Bosch
Dante (voice) / Dante / Mercenary #01 (voice) / Dante / Soldier #1 (voice) / Dan...

Chris Coppola
Enzo (voice) / Enzo / Frat Boy (voice) / Enzo / Officer / Man (voice) / Enzo / M...

Hoon Lee
White Rabbit (voice) / White Rabbit / Horned Demon (voice) / White Rabbit / Pilo...

Kevin Conroy
Baines (voice) / Baines / Mercenary #02 (voice) / Baines / Passerby (voice) / Ba...

Scout Taylor-Compton
Mary (voice) / Mary / Additional Voices (voice)

Benjamin Abiola
Anders (voice) / Anders / Guard (voice) / Anders / Soldier Thief #1 (voice)

Roger L. Jackson
Plasma / Griff (voice) / Additional Voices (voice) / Officer / Interrogator (voi...

Kari Wahlgren
Eva (voice) / Eva / Echidna (voice) / Additional Voices (voice) / Echidna (voice...

Jason Marnocha
Cavaliere (voice) / Civilian / Predator Demon (voice) / Cavaliere / Demon Man (v...

Erica Lindbeck
Woman / Demon Refugee (voice) / Mother / Baby / Demon Kid (voice) / Kalina (voic...

Sunkrish Bala
King (voice)

Zeke Alton
Dr. Fisher / Soldier Thief #2 / Demon (voice) / Dr. Fisher / Kurt / Chuck (voice...

Tina Majorino
Sentry (voice)

Leilani Barrett
Patriot (voice) / Patriot / Cop / Soldier

Fryda Wolff
Ninja / Cop (voice) / Ninja (voice) / Ninja / Demon Woman (voice)

Ray Chase
Arkham / Agni / Rudra (voice) / Rudra / Demon Soldier (voice)

Robbie Daymond
Vergil (voice) / Knight (voice)

Ian James Corlett
Baines (voice)

Jon Gries
Pres. Hopper / Soldier (voice) / Pres. Hopper / Late Night Host (voice)

Matthew Waterson
Large Soldier (voice) / News Anchor / Senator / Priest (voice)