Zoe Saldaña
Princess Maya (voice)

Dee Bradley Baker
Chiapa (voice)

Diego Luna
Zatz (voice)

Gael García Bernal
The Jaguar Brothers (voice)

Allen Maldonado
Rico (voice)

Stephanie Beatriz
Chimi (voice)

Gabriel Iglesias
Piccu (voice)

Alfred Molina
Lord Mictlan (voice)

Kate del Castillo
Lady Micte (voice)

Danny Trejo
Cabrakan (voice)

Rosie Perez
Cipactli (voice)

Cheech Marin
Hura/Can (voice)

Chelsea Rendon
Acat (voice)

Queen Latifah
Gran Bruja (voice)

Wyclef Jean
Gran Brujo (voice)

Eric Bauza
Vucub (voice)

Isabela Merced
Widow Queen (voice)

Rita Moreno
Ah Puch (voice)

Joaquín Cosío
Camazotz (voice)

Carlos Alazraqui
Chivo (voice) / Picchu's Father (voice)