Eric Wareheim
Various

Tim Heidecker
Various

John C. Reilly
Dr. Steve Brule / Dr. Steve Brule (uncredited)

Bob Odenkirk
Announcer (voice) / Cinco Announcer (voice) / Various / Here She Comes Singer / ...

Richard Dunn
Self / Pep Pep / Tim's Dad / Old Office Temp / Tim's Body /

David Liebe Hart
Self

James Quall
Self

Bill A. Jones
Announcer (voice) / Infomercial Announcer (voice) / Announcer / Channel 5 Announ...

Ben Hur
Self /

Ron Austar
Pierre / Bride's Parents / Pierre (uncredited)

Bob Druwing
Self / Lindsay Porch / Child Clown Video Instructor (voice) / Chanter

'Weird Al' Yankovic
Uncle Muscles / Simon

Warren Stearns
Self / Gravy Robber Trainee / Audience Member (uncredited) / Pastor / Self / Old...

Kazu Nagahama
Kaz / Mourner / Kaz / E-Jury Guy / Self / Tiny Hat Wearer / Birthday Party Guest

Zach Galifianakis
Tairy Greene / Tairy Greene as The Snuggler

Will Forte
Will Grello / Pall Willeaux / J.J. Pepper / Dr. Reid Tamaranda

Joey Brander
Seminar Student / Joey Heidecker

Rainn Wilson
Blind Man / Cinco Spokesman / Video Match Client / Bobby Stoan / Bobby Stoan (un...

Palmer Scott
Self / Sit On You Guy / Sit on You Guy

Tanese Gray
Self / Game Player