Cheryl Chase
Angelica Pickles (voice)

Cree Summer
Susie Carmichael (voice)

Tara Strong
Jake (voice)

Pamela Adlon
Lucas (voice)

Grey DeLisle
Dulce (voice)

Vicki Lewis
Ms. Weemer (voice)

Nika Futterman
Matthew (voice)

Shayna Fox
Savannah Shane (voice)

Hope Levy
Kayla (voice)

Pat Musick
Harold Frumpkin (voice)

Amy Gunzenhauser
Leonardo (voice)

Jane Wiedlin
Willy (voice)

Lauren Wood
Clark (voice)

Mo Gaffney
Dr. Yeskel (voice)

Laraine Newman
Julia (voice)

Doug Gochman
Plumber / Clown (voice)

Tress MacNeille
Charlotte Pickles (voice)

Rob Paulsen
Plumber / Fireman / Clown (voice)

Brian George
Emil / Jackson / Coffee Man (voice)

Kimberly Brooks
Noah (voice)