Owen Wilson
Lightning McQueen (voice)

Paul Newman
Doc Hudson (voice)

Bonnie Hunt
Sally Carrera (voice)

Larry the Cable Guy
Mater (voice)

Cheech Marin
Ramone (voice)

Tony Shalhoub
Luigi (voice)

Guido Quaroni
Guido (voice)

Jenifer Lewis
Flo (voice)

Paul Dooley
Sarge (voice)

Michael Wallis
Sheriff (voice)

George Carlin
Fillmore (voice)

Katherine Helmond
Lizzie (voice)

John Ratzenberger
Mack / Hamm Truck / Abominable Snow Plow / P.T. Flea Car (voice)

Michael Keaton
Chick Hicks (voice)

Richard Petty
The King (voice)

Jeremy Piven
Harv (voice)

Bob Costas
Bob Cutlass (voice)

Darrell Waltrip
Darrell Cartrip (voice)

Richard Kind
Van (voice)

Edie McClurg
Minny (voice)