Pete Davidson
Marmaduke (voice)

J.K. Simmons
Zeus (voice)

David Koechner
Phil Winslow (voice)

Mary Hart
EntertainMutt Tonight Host (voice)

Julie Nathanson
Dottie Winslow (voice)

Erin Fitzgerald
Barbara Winslow (voice)

Stephen Stanton
King Tut (voice)

Brian Hull
Guy Hilton (voice)

Sumalee Montano
Amy (voice)

Andrew Morgado
Henri / Phillipe (voice)

Chris Hackney
Announcer (voice)

Shelby Young
Shantrelle (voice)

Johnny Yong Bosch
Zhi (voice)

Nika Futterman
Juan Pedro (voice)

Melissa Disney
Javier (voice)

Fred Tatasciore
Vinnie (voice)

Jason Anthony
Ronnie (voice)

Vanessa Marshall
Phone Girl (voice)

Nickie Bryar
Derek (voice)

Joey Camen
Bee (voice)