James Denton
Superman / Clark Kent (voice)

Christina Hendricks
Lois Lane (voice)

Anthony LaPaglia
Lex Luthor (voice)

Ed Asner
Perry White (voice)

Linda Cardellini
Nasthalthia Luthor (voice)

Matthew Gray Gubler
Jimmy Olsen (voice)

Arnold Vosloo
Bar-El (voice)

Frances Conroy
Martha Kent (voice)

John DiMaggio
Samson / Ultra-Sphinx (voice)

Alexis Denisof
Dr. Leo Quintum (voice)

Chris Cox
Lead Agent (voice)

Steve Blum
Atlas / General Sam Lane / Astronaut #1 (voice)

Obba Babatundé
Judge / Bibliobot (voice)

Robin Atkin Downes
Solaris (voice)

Michael Gough
Parasite (voice)

Finola Hughes
Lilo (voice)

Kevin Michael Richardson
Steve Lombard / Lizard Man / Convict (voice)

Fred Tatasciore
Krull / Robots / Astronaut #2 (voice)

Cathy Cavadini
Floral / Cat Grant (voice)