Anthony Gonzalez
Miguel Rivera (voice)

Gael García Bernal
Héctor (voice)

Benjamin Bratt
Ernesto de la Cruz (voice)

Alanna Ubach
Mamá Imelda (voice)

Renée Victor
Abuelita (voice)

Jaime Camil
Papá (voice)

Alfonso Arau
Papá Julio (voice)

Herbert Siguenza
Tío Oscar / Tío Felipe (voice)

Gabriel Iglesias
Clerk (voice)

Lombardo Boyar
Plaza Mariachi / Gustavo (voice)

Ana Ofelia Murguía
Mamá Coco (voice)

Natalia Cordova-Buckley
Frida Kahlo (voice)

Sofía Espinosa
Mamá (voice)

Selene Luna
Tía Rosita (voice)

Edward James Olmos
Chicharrón (voice)

Carla Medina
Departures Agent / Additional Voices (voice)

Dyana Ortelli
Tía Victoria / Additional Voices (voice)

Blanca Araceli
Emcee (voice)

Salvador Reyes
Security Guard (voice)

Cheech Marin
Corrections Officer (voice)