John Barrymore
Dr. Henry Jekyll / Mr. Edward Hyde

Brandon Hurst
Sir George Carewe

Martha Mansfield
Millicent Carewe

Charles Lane
Dr. Richard Lanyon

Cecil Clovelly
Edward Enfield

Nita Naldi
Miss Gina

Louis Wolheim
Music Hall Proprietor

Alma Aiken
Extra (uncredited)

J. Malcolm Dunn
John Utterson (uncredited)

Ferdinand Gottschalk
Old Man at Table in Music Hall (uncredited)

Julia Hurley
Hyde's Landlady with Lamp (uncredited)

Jack McHugh
Street Kid - Raises Fist to Mr. Hyde (uncredited)

Georgie Drew Mendum
Patron in Music Hall (uncredited)

Blanche Ring
Woman at Table with Old Man in Music Hall (uncredited)

May Robson
Prostitute at Clinic (uncredited)

George Stevens
Jekyll's Butler Poole (uncredited)