Owen Wilson
Lightning McQueen (voice)

Cristela Alonzo
Cruz Ramirez (voice)

Chris Cooper
Smokey (voice)

Nathan Fillion
Sterling (voice)

Larry the Cable Guy
Mater (voice)

Armie Hammer
Jackson Storm (voice)

Ray Magliozzi
Dusty (voice)

Tony Shalhoub
Luigi (voice)

Bonnie Hunt
Sally Carrera (voice)

Lea DeLaria
Miss Fritter (voice)

Kerry Washington
Natalie Certain (voice)

Bob Costas
Bob Cutlass (voice)

Margo Martindale
Louise Nash (voice)

Darrell Waltrip
Darrell Cartrip (voice)

Isiah Whitlock, Jr.
River Scott (voice)

Bob Peterson
Chick Hicks (voice)

Guido Quaroni
Guido (voice)

Tom Magliozzi
Rusty (voice)

John Ratzenberger
Mack (voice)

Kyle Petty
Cal Weathers (voice)