Basil Rathbone
Sherlock Holmes

Nigel Bruce
Dr. John H. Watson

Patricia Morison
Mrs. Hilda Courtney

Frederick Worlock
Colonel Cavanaugh

Harry Cording
Hamid

Carl Harbord
Inspector Hopkins

Holmes Herbert
Ebenezer Crabtree

Edmund Breon
Julian 'Stinky' Emery

Patricia Cameron
Evelyn Clifford

Mary Gordon
Mrs. Hudson

Ian Wolfe
Commissioner of Scotland Yard

Leyland Hodgson
Tour Guide

Marjorie Bennett
Antique Shop Assistant (uncredited)

William H. O'Brien
Detective at Murder Scene

Frank Baker
Photographer

Sally Shepherd

Wallace Scott
Joe Cisto

Jack Curtis
Pub Patron (uncredited)

Cyril Delevanti
Convict at Dartmoor Prison (uncredited)

Charlie Hall
Cab Driver (uncredited)