Basil Rathbone
Sherlock Holmes

Nigel Bruce
Doctor Watson

Lionel Atwill
Professor Moriarty

William Post Jr.
Dr. Franz Tobel

Kaaren Verne
Charlotte Eberli

Dennis Hoey
Inspector Lestrade

Holmes Herbert
Sir Reginald

Mary Gordon
Mrs. Hudson

Harry Cording
Jack Brady (uncredited)

Harold De Becker
Peg Leg (uncredited)

Paul Fix
Mueller (uncredited)

Henry Victor
Professor Frederic Hoffner (uncredited)

John Burton
RAF Officer (uncredited)

Paul Bryar
Swiss Waiter (uncredited)

Whit Bissell
London Bobbie (uncredited)

Rudolph Anders
Braun (uncredited)

Colin Kenny
Scotland Yard Detective (uncredited)

George Burr Macannan
Gottfried (uncredited)

Harry Woods
Kurt (uncredited)