James Cagney
Tom Powers

Jean Harlow
Gwen Allen

Edward Woods
Matt Doyle

Joan Blondell
Mamie

Donald Cook
Mike Powers

Leslie Fenton
Samuel 'Nails' Nathan

Beryl Mercer
Ma Powers

Robert Emmett O'Connor
Paddy Ryan

Murray Kinnell
Putty Nose

Clark Burroughs
Dutch (uncredited)

Mae Clarke
Kitty (uncredited)

Frank Coghlan Jr.
Tom as a Boy (uncredited)

George Daly
Machine Gunner (uncredited)

Frankie Darro
Matt as a Boy (uncredited)

Snitz Edwards
Miller (uncredited)

Rita Flynn
Molly Doyle (uncredited)

Dorothy Gee
Nails' Girl (uncredited)

Douglas Gerrard
Assistant Tailor (uncredited)

Dorothy Gray
Little Girl (uncredited)

Ben Hendricks Jr.
'Bugs' Moran as a Boy (uncredited)