Matthew Perry
Self (archive footage)

Morgan Fairchild
Self

E. Martin Estrada
Self - U.S. Attorney for the Central District of California

Katy Forrester
Self - Journalist

Self - Journalist

Greg Kading
Self - LAPD Detective

Self - LAPD Detective

Deborah Walker
Self - Journalist

Self - Journalist

David Feifel
Self - Kadima Neuropsychiatry Institute

Anna David
Self - Author

Self - Author

Hank Azaria
Self - Actor & Matthew's Friend

Jennifer O'Neill
Self - Former Celebrity Assistant

Jennifer Aniston
Self - Actor & Co-Star (archive footage)

Mark Chavez
Self - Physician (archive footage)

Courteney Cox
Self - Actor & Co-Star (archive footage)

Savannah Guthrie
Self - Co-Host

Self - Co-Host

Kenneth Iwamasa
Self - Matthew's Personal Assistant (archive footage)

David Letterman
Self - Host

Self - Host

Cody McLaury
Self - Ketamine Overdose Victim (archive footage)

Caitlin Morrison
Self - Matthew's Sister (archive footage)

Keith Morrison
Self - Matthew's Stepfather (archive footage)

John Bennett Perry
Self - Matthew's Father (archive footage)