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Ed Asner
Carl Fredricksen (voice)

Christopher Plummer
Charles F. Muntz (voice)

Jordan Nagai
Russell (voice)

Bob Peterson
Dug / Alpha (voice)

Delroy Lindo
Beta (voice)

John Ratzenberger
Construction Foreman Tom (voice)

David Kaye
Newsreel Announcer (voice)

Elie Docter
Young Ellie (voice)

Jeremy Leary
Young Carl (voice)

Mickie McGowan
Police Officer Edith (voice)

Danny Mann
Construction Worker Steve (voice)

Donald Fullilove
Nurse George (voice)

Jess Harnell
Nurse AJ (voice)

Bob Bergen
Additional Voices (voice)

John Cygan
Additional Voices (voice)

Paul Eiding
Additional Voices (voice)

Teresa Ganzel
Additional Voices (voice)

Sherry Lynn
Additional Voices (voice)

Laraine Newman
Additional Voices (voice)

Teddy Newton
Additional Voices (voice)