Andy Samberg
Ham III (voice)

Cheryl Hines
Luna (voice)

Jeff Daniels
Zartog (voice)

Patrick Warburton
Titan (voice)

Kristin Chenoweth
Kilowatt (voice)

Kenan Thompson
Ringmaster (voice)

Zack Shada
Comet / Nava Boy (voice)

Carlos Alazraqui
Houston (voice)

Omid Abtahi
Dr. Jagu (voice)

Patrick Breen
Dr. Bob (voice)

Jane Lynch
Dr. Poole (voice)

Kath Soucie
Dr. Smothers (voice)

Stanley Tucci
Senator (voice)

Wally Wingert
Splork / Infinity Probe / Pappy Ham (voice)

Jessica Gee-George
Ship Voice / Infinity Probe / Additional Voices (voice)

Tom Kenny
Newsreel (voice)

Jason Harris
Guard (voice)

Jess Harnell
Additional Voices (voice)

Ellie Harvie
Additional Voices (voice)