John Wayne
Lt. Col. Kirby Yorke

Maureen O'Hara
Mrs. Kathleen Yorke

Ben Johnson
Trooper Travis Tyree

Claude Jarman Jr.
Trooper Jefferson 'Jeff' Yorke

Harry Carey, Jr.
Trooper Daniel 'Sandy' Boone

Chill Wills
Dr. Wilkins

J. Carrol Naish
Lt. Gen. Philip Sheridan

Victor McLaglen
Sgt. Maj. Timothy Quincannon

Grant Withers
U.S. Deputy Marshal

Peter Ortiz
Capt. St. Jacques

Steve Pendleton
Capt. Prescott

Karolyn Grimes
Margaret Mary

Alberto Morin
Lieutenant

Stan Jones
Sergeant

Fred Kennedy
Trooper Heinze

Ken Curtis
Donnelly - Regimental Singer (uncredited)

Tommy Doss
Regimental Singer (uncredited)

Hugh Farr
Regimental Singer (uncredited)

Karl Farr
Regimental Singer (uncredited)

Shug Fisher
Regimental Singer/Bugler (uncredited)