Michael J. Fox
Stuart Little (voice)

Geena Davis
Mrs. Little

Hugh Laurie
Mr. Little

Jonathan Lipnicki
George Little

Nathan Lane
Snowbell (voice)

Chazz Palminteri
Smokey (voice)

Steve Zahn
Monty (voice)

Jim Doughan
Lucky (voice) / Officer Allen

David Alan Grier
Red (voice)

Bruno Kirby
Mr. Stout (voice)

Jennifer Tilly
Mrs. Stout (voice)

Stan Freberg
Race Announcer (voice)

Jeffrey Jones
Uncle Crenshaw

Connie Ray
Aunt Tina

Allyce Beasley
Aunt Beatrice

Brian Doyle-Murray
Cousin Edgar

Estelle Getty
Grandma Estelle

Harold Gould
Grandpa Spencer

Patrick Thomas O'Brien
Uncle Stretch

Julia Sweeney
Mrs. Keeper