Michael J. Fox
Stuart Little (voice)

Chazz Palminteri
Smokey (voice)

Nathan Lane
Snowbell (voice)

Geena Davis
Mrs. Little

Hugh Laurie
Mr. Little

Jonathan Lipnicki
George Little

David Alan Grier
Red (voice)

Steve Zahn
Monty (voice)

Jim Doughan
Lucky / Officer Allen (voice)

Bruno Kirby
Mr. Stout (voice)

Jennifer Tilly
Mrs. Stout (voice)

Stan Freberg
Race Announcer (voice)

Jeffrey Jones
Uncle Crenshaw

Connie Ray
Aunt Tina

Allyce Beasley
Aunt Beatrice

Brian Doyle-Murray
Cousin Edgar

Estelle Getty
Grandma Estelle

Harold Gould
Grandpa Spencer

Patrick Thomas O'Brien
Uncle Stretch

Julia Sweeney
Mrs. Keeper